关键词: 口腔外科手术, 瑞马唑仑, 瑞芬太尼, 镇痛, 镇静

Abstract: Objective: To explore the effects of remimazolam combined with remifentanil on oral surgery. Methods: A total of 94 patients who underwent oral surgery at Dalian Stomatological Hospital were selected as the research subjects and divided into the experimental group and the control group according to a random number table method, with 47 cases in each group. The control group was induced anesthesia by target-controlled pump injection of remifentanil and propofol, while the experimental group was induced anesthesia by target-controlled pump injection of remifentanil and intravenous injection of remimazolam besylate. The hemodynamic indicators heart rate (HR) and mean arterial pressure (MAP), perioperative analgesic and sedative effects, and the occurrence of adverse reactions during and after the operation were compared between the two groups after entering the room (T0), after the completion of anesthesia induction (T1), at the beginning of the operation (T2), and at the end of the operation (T3). Results: HR and MAP in both groups showed a trend of first decreasing and then increasing (P<0.05), and HR and MAP of the experimental group were lower from T2 to T3 (P<0.05). The visual analogue scale (VAS) of the two groups showed a trend of first decreasing and then increasing (P<0.05), and the VAS score of the experimental group was lower at 2 hours, 6 hours, 24 hours after the operation (P<0.05). The Ramsay scores of the two groups showed a trend of increasing first and then decreasing (P<0.05), and the Ramsay score of the experimental group was lower from T0 to T3 (P<0.05). There was no statistically significant difference in the incidence of intraoperative and postoperative adverse events between the two groups (P>0.05). Conclusions: Remimazolam combined with remifentanil in oral surgery can effectively reduce intraoperative hemodynamic fluctuations in patients, exert good analgesic and sedative effects, and have relatively few adverse reactions, which can provide a reference for clinical application.

Key words: oral surgery, remazolam, remifentanil, analgesia, sedation