自体皮质骨联合含重组人骨形态发生蛋白2磷酸钙骨粉修复牙槽突裂的探索性研究

doi:10.12337/zgkqjxjyzz.2024.02.002

中国口腔医学继续教育杂志 ›› 2024, Vol. 27 ›› Issue (2): 124-131.DOI: 10.12337/zgkqjxjyzz.2024.02.002

自体皮质骨联合含重组人骨形态发生蛋白2磷酸钙骨粉修复牙槽突裂的探索性研究

赵欣然^#, 解嘉慧^#, 虞祖音, 庞雪菲, 蔡鸣^*

上海交通大学医学院附属第九人民医院口腔颅颌面科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,中国医学科学院口腔颌面再生医学创新单元,上海市黄浦区制造局路639号,200011

出版日期:2024-03-31 发布日期:2024-09-23
通讯作者: ^*蔡鸣,联系方式：021-23271699-5655,电子邮箱：zidanecm500@126.com,通讯地址：上海市黄浦区制造局路639号,200011
作者简介:^#共同第一作者
基金资助:
三明治法微创修复单侧牙槽突裂成骨效果的随机对照研究,上海市重中之重研究中心（项目编号：2022ZZ01017）; 中国医学科学院医学与健康科技创新工程项目资助（项目编号：2019-I2M-5-037）; 国家口腔疾病临床医学研究中心（上海九院）“口腔医学临床研究攻关项目（非定向项目）”（项目编号：NCRCO202328）

Clinical Observation of Alveolar Bone Graft with Autogenous Cortical Bone Combined with Calcium Phosphate Cement Powder Containing Recombinant Human Bone Morphogenetic Protein-2

Xinran Zhao^#, Jiahui Xie^#, Zuyin Yu, Xuefei Pang, Ming Cai^*

Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, No. 639 Zhizaoju Road, Huangpu District, Shanghai , P.R. China

Online:2024-03-31 Published:2024-09-23
Contact: Ming Cai. Tel: 021-23271699-5655. Email: zidanecm500@126.com. Address: No.639 Zhizaoju Road, Huangpu District, Shanghai 200011, P.R. China.
About author:^#These two authors contributed equally to this work.
Supported by:
Osteogenic Effect of Minimally Invasive Unilateral Alveolar Cleft Repair Using Sandwich Like Bone Graft: A randomized controlled study, Shanghai’s Top Priority Research Center, Grant/Award (No.2022ZZ01017) CAMS Innovation Fund for Medical Sciences (CIFMS), Grant/Award (No.2019-I2M-5-037) National Clinical Research Center for Oral Diseases (Shanghai Ninth People’s Hospital) Clinical Research Project for Oral Medicine, Grant/Award (No. NCRCO202328)

摘要/Abstract

摘要： 目的：总结采用下颌单层皮质骨联合负载重组人骨形态发生蛋白2的自固化磷酸钙骨粉移植修复牙槽突裂的成骨效果。方法：回顾2020年12月至2021年11月间上海第九人民医院口腔颅颌面科采用上述方法治疗的牙槽突裂病例,分析成骨效果及并发症发生情况。结果：共纳入病例8例,平均骨吸收率28.88%, 1例发生伤口裂开,经过治疗仍疗效良好;1例术后2周伤口裂开伴感染,术后6月拍摄电子计算机断层扫描发现移植骨与周围骨不连续,术后8月时皮质骨从裂开处排出,其余6例随访期间无明显并发症。结论：下颌单层皮质骨联合负载重组人骨形态发生蛋白2的自固化磷酸钙骨粉移植修复牙槽突裂效果良好,骨吸收率低,新生骨密度高,创伤小,具有临床推广价值。

关键词: 下颌单层皮质骨, 植骨术, 重组人骨形态发生蛋白2, 自固化磷酸钙, 牙槽突裂植骨术

Abstract: Objective: To summarize the osteogenic effect of monocortical mandibular bone combined with calcium phosphate cement (CPC) powder containing recombinant human bone morphogenetic protein-2 (rhBMP-2) in alveolar bone graft. Methods: Patients with alveolar cleft treated by the above methods from December 2020 to November 2021 were reviewed, and the bone resorption and complications were analyzed. Results: A total of 8 cases were included, the average bone resorption rate was 28.88%. One case had wound dehiscence, and the curative effect was still good after treatment. One case suffered from wound dehiscence and infection 2 weeks after operation. The CT scan at 6 months after operation indicated that the graft bone was not continuous with the surrounding bone. At 8 months after operation, the bone block was discharged from the dehiscence. Conclusions: The effect of monocortical mandibular bone combined with CPC powder containing rhBMP-2 in repairing alveolar cleft was acceptable with lower bone absorption rate, higher new bone density, less trauma, and thus valuable clinical application.

Key words: monocortical mandible bone, bone graft, recombinant human bone morphogenetic protein-2, calcium phosphate cement, alveolar bone graft

赵欣然, 解嘉慧, 虞祖音, 庞雪菲, 蔡鸣. 自体皮质骨联合含重组人骨形态发生蛋白2磷酸钙骨粉修复牙槽突裂的探索性研究[J]. 中国口腔医学继续教育杂志, 2024, 27(2): 124-131.

Xinran Zhao, Jiahui Xie, Zuyin Yu, Xuefei Pang, Ming Cai. Clinical Observation of Alveolar Bone Graft with Autogenous Cortical Bone Combined with Calcium Phosphate Cement Powder Containing Recombinant Human Bone Morphogenetic Protein-2[J]. Chinese Journal of Stomatological Continuing Education, 2024, 27(2): 124-131.

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自体皮质骨联合含重组人骨形态发生蛋白2磷酸钙骨粉修复牙槽突裂的探索性研究

Clinical Observation of Alveolar Bone Graft with Autogenous Cortical Bone Combined with Calcium Phosphate Cement Powder Containing Recombinant Human Bone Morphogenetic Protein-2

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