浓缩生长因子用于下颌低位阻生第三磨牙拔除术的随机对照临床研究

doi:10.12337/zgkqjxjyzz.2025.03.007

中国口腔医学继续教育杂志 ›› 2025, Vol. 28 ›› Issue (3): 158-165.DOI: 10.12337/zgkqjxjyzz.2025.03.007

浓缩生长因子用于下颌低位阻生第三磨牙拔除术的随机对照临床研究

马君^1,2,3, 柏乐^1,2, 杨鑫^1,2, 崔浩^1,2, 那思家^1,2, 屠军波^1,2, 梁想^1,2,*

¹陕西省颅颌面精准医学研究重点实验室;
²西安交通大学口腔医院颌面外科门诊;
³西宁市口腔医院口腔颌面外科门诊

出版日期:2025-05-31 发布日期:2025-05-31
通讯作者: ^*梁想,联系方式：029-87215336,电子邮箱：1529643062@qq.com,通讯地址：陕西省西安市新城区西五路98号,710004
基金资助:
陕西省牙颌疾病临床医学研究中心开放课题（项目编号：2021YHJB08）; 陕西省卫生健康口腔颌面外科科研创新团队（项目编号：2024TD-19）

A Randomized Controlled Clinical Study of Concentrated Growth Factor for Extraction of Mandibular Lower Impacted Third Molars

Jun Ma^1,2,3, Le Bai^1,2, Xin Yang^1,2, Hao Cui^1,2, Sijia Na^1,2, Junbo Tu^1,2, Xiang Liang^1,2,*

¹Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi’an, Shaanxi Province, P.R. China;
²Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Xi’an, Shaanxi Province, P.R. China;
³Oral and Maxillofacial Surgery Outpatient Department, Xining Stomatological Hospital, Xining, Qinghai Province, P.R. China

Online:2025-05-31 Published:2025-05-31
Contact: Xiang Liang. Tel: 029-87215336. Email: 1529643062@qq.com. Address: No. 98, West 5th Road, Xincheng District, Xi’an 710004, Shaanxi Province, P.R. China.
Supported by:
Open Research Project of Shaanxi Provincial Clinical Research Center for Dento-Maxillofacial Diseases (No.2021YHJB08); The Research and Innovation Team for Oral and Maxillofacial Surgery at the Shaanxi Provincial Health and Wellness Commission (No.2024TD-19)

摘要/Abstract

摘要： 目的：探讨浓缩生长因子（concentrated growth factor,CGF）对下颌低位埋伏阻生第三磨牙拔除后并发症的缓解及软硬组织愈合修复的影响。方法：选取50例双侧对称埋伏下颌阻生第三磨牙患者随机分为试验组与对照组,拔牙术后使用CGF的为试验组,常规拔牙的为对照组。对比术后第1、第3、第7天疼痛、肿胀、软组织愈合等术后并发症,及术后3个月第二磨牙牙周袋和拔牙创愈合情况。结果：术后7天试验组创口愈合指数优于对照组（P<0.01）。术后1、3天试验组较对照组局部肿胀缓解明显（P<0.001）,第7天时两组未见明显差异。术后第1天视觉模拟评分无统计学差异（P=0.250）,术后第3、7天试验组疼痛评分低于对照组（P=0.001）。试验组与对照组牙槽嵴宽度及颊舌侧骨壁高度对比具有统计学差异（P<0.001）。试验组骨密度显著高于对照组。试验组牙周袋改善情况具有显著性差异（P<0.001）。结论：下颌低位埋伏第三磨牙拔除术后局部应用CGF可以有效促进伤口愈合、缓解局部肿胀、疼痛等并发症并促进组织再生。

关键词: 下颌低位埋伏阻生第三磨牙, 浓缩生长因子, 并发症, 组织愈合, 拔牙术

Abstract: Objective: To investigate the effect of concentrated growth factor (CGF) on the relief of complications and the healing and repair of soft and hard tissue after extraction of lower mandibular impacted third molar. Methods: Fifty patients with lower impacted third molars were randomly divided into experimental group and control group. Postoperative complications pain, swelling and soft tissue healing were compared at 1, 3 and 7 days after surgery, and the second molar pocket and alveolar bone tissue healing were compared 3 months later. Results: The wound healing index of experimental group was better than that of control group 7 days after operation (P<0.01). CGF alleviated local swelling 1 and 3 days after operation (P<0.001), and there was no significant difference between CGF and CGF on day 7. There was no statistical significance in visual simulation scores on the first day after surgery (P=0.250), and experimental group were lower than those on the control group on the 3rd and 7th day after surgery (P=0.001). There were significant differences in alveolar ridge width and buccal-lingual wall height between experimental group and control group (P<0.001). Bone density in experimental group was significantly higher than that in control group. The improvement of periodontal pocket in experimental group was significantly different (P<0.001). Conclusions: Local application of CGF can effectively promote wound healing, relieve local swelling and pain, and promote tissue regeneration after the extraction of lower mandibular third molar.

Key words: impacted third molar in lower jaw, CGF, complications, tissue healing, tooth extraction

马君, 柏乐, 杨鑫, 崔浩, 那思家, 屠军波, 梁想. 浓缩生长因子用于下颌低位阻生第三磨牙拔除术的随机对照临床研究[J]. 中国口腔医学继续教育杂志, 2025, 28(3): 158-165.

Jun Ma, Le Bai, Xin Yang, Hao Cui, Sijia Na, Junbo Tu, Xiang Liang. A Randomized Controlled Clinical Study of Concentrated Growth Factor for Extraction of Mandibular Lower Impacted Third Molars[J]. Chinese Journal of Stomatological Continuing Education, 2025, 28(3): 158-165.

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浓缩生长因子用于下颌低位阻生第三磨牙拔除术的随机对照临床研究

A Randomized Controlled Clinical Study of Concentrated Growth Factor for Extraction of Mandibular Lower Impacted Third Molars

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