Abstract: Objective: This case reported the diagnosis and treatment for oral lichenoid lesions of chronic graft-versus-host disease, aiming to explore its clinical characteristics and individualized treatment strategies. Diagnosis and Treatment: After bone marrow transplantation, the patient developed white reticular striae in the oral mucosa accompanied by refractory large atrophic and erosive lesions. To avoid the impact of systemic medication on the underlying disease and hepatorenal function, we developed and implemented an individualized and staged topical treatment strategy. Results: Through multi-stage local comprehensive treatment, the atrophic and erosive lesions healed, the white reticular striae relieved significantly, and the pain alleviated completely. Conclusions: Oral lichenoid lesions of chronic graft-versus-host disease is a potential malignant oral disease. This case indicated that for patients with systemic diseases and complex medication regimen, an individualized treatment strategy with primarily topical therapy could effectively promote the healing of the lesions with safety, which has important clinical reference significance.

Key words: bone marrow transplantation, chronic graft-versus-host disease, oral lichenoid lesions, topical medication therapy, individualized therapy