磁共振波谱对脑内代谢物检测的研究现状

doi:10.12337/zgkqjxjyzz.2023.06.001

中国口腔医学继续教育杂志 ›› 2023, Vol. 26 ›› Issue (6): 433-437.DOI: 10.12337/zgkqjxjyzz.2023.06.001

• 综述 • 下一篇

磁共振波谱对脑内代谢物检测的研究现状

张俸玮^*

上海交通大学医学院附属第九人民医院麻醉科

出版日期:2023-11-30 发布日期:2024-03-13
通讯作者: ^*张俸玮,联系方式：17852061788,邮箱：zhangfwei98@163.com,通讯地址：上海市黄浦区制造局路639号,200011

Research Status of Magnetic Resonance Spectroscopy for the Detection of Metabolites in Brain

Fengwei Zhang^*

Department of Anesthesiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine

Online:2023-11-30 Published:2024-03-13
Contact: ^*Fengwei Zhang. Tel: 17852061788. Email: zhangfwei98@163.com. Address: Department of Anesthesiology, 9th Floor, Building 1, Shanghai Ninth Hospital, 639 Manufacturing Bureau Road, Huangpu District, Shanghai 200011, P.R. China.

摘要/Abstract

摘要： 磁共振波谱作为一种非侵入性检测脑内代谢物含量的影像学方法,在临床评估神经系统疾病方面发挥重要作用。人体脑内代谢物水平异常可能引起神经系统疾病。本文对磁共振波谱在脑内代谢物检测的研究现状及部分临床应用进行了综述。

关键词: 磁共振波谱, 脑内代谢物, 神经系统疾病诊断, 全身麻醉, 术后认知功能障碍

Abstract: Magnetic resonance spectroscopy, is a non-invasive imaging method to detect metabolite content in the brain, plays an important role in the clinical assessment of neurological diseases. Abnormal metabolite levels may cause neurological diseases. This paper reviews the research status and some clinical applications of magnetic resonance spectroscopy in the detection of metabolites in brain.

Key words: magnetic resonance spectrum, brain metabolites, diagnosis of neurological diseases, general anesthesia, postoperative cognitive dysfunction

张俸玮. 磁共振波谱对脑内代谢物检测的研究现状[J]. 中国口腔医学继续教育杂志, 2023, 26(6): 433-437.

Fengwei Zhang. Research Status of Magnetic Resonance Spectroscopy for the Detection of Metabolites in Brain[J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(6): 433-437.

参考文献

[1] Rundshagen I.Postoperative cognitive dysfunction[J]. Dtsch Arztebl Int. 2014; 111(8):119-125.
[2] Andersen JV, Schousboe A, Verkhratsky A.Astrocyte energy and neurotransmitter metabolism in Alzheimer’s disease: Integration of the glutamate/GABA-glutamine cycle[J]. Prog Neurobiol. 2022; 217:102331.
[3] Henning A.Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review[J]. Neuroimage. 2018; 168:181-198.
[4] Tumati S, Martens S, Aleman A.Magnetic resonance spectroscopy in mild cognitive impairment: systematic review and meta-analysis[J]. Neurosci Biobehav Rev. 2013; 37(10 Pt 2):2571-2586.
[5] Fujima N, Carlota Andreu-Arasa V, Barest GD, et al. Magnetic Resonance Spectroscopy of the Head and Neck: Principles, Applications, and Challenges[J]. Neuroimaging Clin N Am. 2020; 30(3):283-293.
[6] García-Figueiras R, Baleato-González S, Padhani AR, et al.Proton magnetic resonance spectroscopy in oncology: the fingerprints of cancer[J]? Diagn Interv Radiol. 2016; 22(1):75-89.
[7] Rhodes CJ.Magnetic resonance spectroscopy[J]. Sci Prog. 2017; 100(3):241-292.
[8] Haga KK, Khor YP, Farrall A, et al.A systematic review of brain metabolite changes, measured with 1H magnetic resonance spectroscopy, in healthy aging. Neurobiol Aging[J]. 2009; 30(3):353-363.
[9] Hellström J, Romanos Zapata R, Libard S, et al.The value of magnetic resonance spectroscopy as a supplement to MRI of the brain in a clinical setting[J]. PLoS One. 2018; 13(11):e0207336.
[10] Soares DP, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications[J]. Clin Radiol.2009 Jan; 64(1):12-21.
[11] Bertholdo D, Watcharakorn A, Castillo M.Brain proton magnetic resonance spectroscopy: introduction and overview[J]. Neuroimaging Clin N Am. 2013; 23(3):359-380.
[12] Bolan PJ.Magnetic resonance spectroscopy of the breast: current status[J]. Magn Reson Imaging Clin N Am. 2013; 21(3):625-639.
[13] Chabert J, Allauze E, Pereira B, et al.Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies[J]. Int J Mol Sci. 2022; 23(16):8974.
[14] La PL, Joyce JM, Bell TK, et al.Brain metabolites measured with magnetic resonance spectroscopy in pediatric concussion and orthopedic injury: An Advancing Concussion Assessment in Pediatrics (A-CAP) study[J]. Hum Brain Mapp. 2023; 44(6):2493-2508.
[15] Veeramuthu V, Seow P, Narayanan V, et al.Neurometabolites Alteration in the Acute Phase of Mild Traumatic Brain Injury (mTBI): An In Vivo Proton Magnetic Resonance Spectroscopy (1H-MRS) Study[J]. Acad Radiol. 2018; 25(9):1167-1177.
[16] Guo Z, Liu X, Hou H, et al.(1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer’s disease[J]. Compr Psychiatry. 2016; 69:179-85.
[17] Rodríguez-Nieto G, Levin O, Hermans L, et al.Organization of neurochemical interactions in young and older brains as revealed with a network approach: Evidence from proton magnetic resonance spectroscopy (1H-MRS)[J]. Neuroimage. 2023; 266:119830.
[18] Rietzler A, Steiger R, Mangesius S, et al.Energy metabolism measured by 31P magnetic resonance spectroscopy in the healthy human brain[J]. J Neuroradiol. 2022; 49(5):370-379.
[19] Meyerhoff DJ.Brain proton magnetic resonance spectroscopy of alcohol use disorders[J]. Handb Clin Neurol. 2014; 125:313-337.
[20] Bittšanský M, Výbohová D, Dobrota D.Proton magnetic resonance spectroscopy and its diagnostically important metabolites in the brain[J]. Gen Physiol Biophys. 2012; 31(1):101-112.
[21] Lin X, Chen Y, Zhang P, et al.The potential mechanism of postoperative cognitive dysfunction in older people[J]. Exp Gerontol. 2020; 130:110791.
[22] Andersen JV, Christensen SK, Westi EW, et al.Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer’s disease[J]. Neurobiol Dis. 2021; 148:105198.
[23] McCarthy L, Verma G, Hangel G, et al. Application of 7T MRS to High-Grade Gliomas[J]. AJNR Am J Neuroradiol. 2022; 43(10):1378-1395.
[24] Nummela AJ, Laaksonen LT, Laitio TT, et al.Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy[J]. Eur J Anaesthesiol. 2022; 39(6):521-532.
[25] Boretius S, Tammer R, Michaelis T, et al.Halogenated volatile anesthetics alter brain metabolism as revealed by proton magnetic resonance spectroscopy of mice in vivo[J]. Neuroimage. 2013; 69:244-255.
[26] Söbbeler FJ, Carrera I, Pasloske K, et al.Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)[J]. BMC Vet Res. 2018; 14(1):69.

磁共振波谱对脑内代谢物检测的研究现状

Research Status of Magnetic Resonance Spectroscopy for the Detection of Metabolites in Brain

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics

本文评价

[1]	罗林, 蒋琳琳, 杨燃, 吉阳. 先天性心脏病患儿全身麻醉下口腔治疗的术前风险评估[J]. 中国口腔医学继续教育杂志, 2023, 26(6): 467-473.
[2]	王沛娟, 刘冰, 吴宇飞, 张百泽, 张惠. 颅颌面发育畸形伴低龄儿童龋患儿全身麻醉下口腔治疗1例[J]. 中国口腔医学继续教育杂志, 2023, 26(6): 489-498.