芹黄素对拔牙创早期骨愈合影响的实验研究

中国口腔医学继续教育杂志 ›› 2021, Vol. 24 ›› Issue (6): 393-397.

芹黄素对拔牙创早期骨愈合影响的实验研究

汝璐^1,2, 张君^2,3, 王雅琦², 陈治宇¹, 徐文惠¹, 王晗溪¹, 王旭霞^1,2,3

¹山东大学齐鲁医学院口腔医学院（口腔医院）口腔颌面外科;
²山东省口腔组织再生重点实验室;
³山东省口腔生物材料与组织再生工程实验室山东济南文化西路44-1号 250012

出版日期:2021-11-30 发布日期:2022-03-01
通讯作者: 王旭霞口腔颌面外科临床与基础研究 ,联系方式 13906410670,电子邮箱 wxx@sdu.edu.cn
基金资助:
山东省自然科学基金项目（ZR2019MH113）山东省研究生教育质量提升计划项目（syal1705）

Online:2021-11-30 Published:2022-03-01

摘要/Abstract

摘要： 目的芹黄素是一种广泛分布的植物类黄酮,本研究通过动物实验,探讨芹黄素对于拔牙创早期骨愈合的影响。方法选取24只8周Wistar雄性大鼠,将其随机分为低剂量组、高剂量组、对照组3组,拔除右上颌第一磨牙,腹腔注射芹黄素溶液（10mg/kg、50mg/kg、0mg/kg）,每两天注射一次。在拔牙后28天处死全部大鼠,分离右上颌骨,进行Micro CT扫描及制作石蜡切片。切片行HE染色和OPG、RANKL免疫组织化学染色。采用Prism 7.0软件包对数据进行统计学分析。结果 HE染色及Micro CT扫描显示加药组拔牙创愈合程度优于对照组。芹黄素可以促进OPG的表达(P<0.05）,同时降低RANKL的表达（P<0.05）。结论芹黄素对于大鼠拔牙创早期的骨愈合具有促进作用。

关键词: 芹黄素, 拔牙创, 早期, 骨愈合

汝璐, 张君, 王雅琦, 陈治宇, 徐文惠, 王晗溪, 王旭霞. 芹黄素对拔牙创早期骨愈合影响的实验研究[J]. 中国口腔医学继续教育杂志, 2021, 24(6): 393-397.

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