复发性阿弗他溃疡粘附性药物递送研究进展

doi:10.12337/zgkqjxjyzz.2025.06.003

中国口腔医学继续教育杂志 ›› 2025, Vol. 28 ›› Issue (6): 393-397.DOI: 10.12337/zgkqjxjyzz.2025.06.003

复发性阿弗他溃疡粘附性药物递送研究进展

陈晓菊¹, 赵忠芳^2,*, 何肖翰³, 刘斌^1,*

¹兰州大学口腔医学院（口腔医院）·口腔修复科;
²兰州大学口腔医学院（口腔医院）·牙周黏膜科;
³兰州大学口腔医学院（口腔医院）·口腔正畸科

出版日期:2025-11-30 发布日期:2025-11-30
通讯作者: ^*赵忠芳,联系方式：0931-7716666,电子邮箱：zzfkq2015@126.com,通讯地址：甘肃省兰州市城关区东岗西路199号,730000;刘斌,联系方式：0931-8915003,电子邮箱：liubkq@lzu.edu.cn,通讯地址：甘肃省兰州市城关区东岗西路199号,730000
基金资助:
甘肃省联合科研基金重大项目头颈部肿瘤精准放射治疗技术及相关机制研究（项目编号：24JRRA941）;甘肃省联合基金项目E3泛素连接酶N4L在牙周炎发生发展中的功能及机制研究（项目编号:24JRRA943）;兰州大学口腔医院青年基金项目溃疡、糜烂类黏膜病激光治疗参数的探究及相关临床指南初探（项目编号:lzukqky-2022-t10）

Advances in Adhesive Drug Delivery for Recurrent Aphthous Ulcers

Xiaoju Chen¹, Zhongfang Zhao^2,*, Xiaohan He³, Bin Liu^1,*

¹Department of Prosthodontics, School / Hospital of Stomatology Lanzhou University;
²Department of Periodontology and Mucosal Diseases, School / Hospital of Stomatology Lanzhou University;
³Department of Orthodontics, School / Hospital of Stomatology Lanzhou University, Lanzhou, P.R. China

Online:2025-11-30 Published:2025-11-30
Contact: Zhongfang Zhao. Tel: 0931-7716666. Email: zzfkq2015@126.com. Address: No. 199, Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, P.R. China; Bin Liu. Tel: 0931-8915003. Email: liubkq@lzu.edu.cn. Address: No. 199, Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, P.R. China.
Supported by:
Major Project of the Joint Research Fund of Gansu Province (No.24JRRA941); Joint Fund Project of Gansu Province (No.24JRRA943); The Youth Fund Project of Lanzhou University School and Hospital of Stomatology (No.lzukqky-2022-t10)

摘要/Abstract

摘要： 复发性阿弗他溃疡（recurrent aphthous ulcer,RAU）是临床常见的口腔黏膜疾病,以反复发作的圆形或椭圆形疼痛性溃疡为特征。其治疗目标侧重于减少复发频率、减轻疼痛和促进愈合。局部治疗是主要手段,其中,包载药物的可粘附性口腔黏膜药物递送系统因具备靶向递药能力、可延长驻留时间而备受关注。本文综述了用于RAU治疗的可粘附性药物递送系统,包括柔性膜、贴片和微针贴片等的研究进展,分析了其设计策略与优势,并探讨了当前存在的不足之处,以期为未来研究提供思路与启发。

关键词: 复发性阿弗他溃疡, 湿粘附性, 口腔局部药物递送, 水凝胶, 微针贴片

Abstract: Recurrent aphthous ulcer (RAU) is a prevalent oral mucosal disorder characterized by painful, recurrent round or oval-shaped ulcers. Treatment aims to reduce recurrence frequency, alleviate pain, and accelerate healing. Local therapy is the mainstay, among which adhesive oral mucosal drug delivery systems are promising for targeted and prolonged drug action. This review summarizes advances in such systems for RAU treatment, including flexible films, patches, and microneedle patches. It analyzes the design strategies and advantages of these systems, and points out their shortcomings, with the aim of providing ideas and inspiration for further research.

Key words: recurrent aphthous ulcer, wet adhesion, oral local drug delivery, hydrogel, microneedle patch

陈晓菊, 赵忠芳, 何肖翰, 刘斌. 复发性阿弗他溃疡粘附性药物递送研究进展[J]. 中国口腔医学继续教育杂志, 2025, 28(6): 393-397.

Xiaoju Chen, Zhongfang Zhao, Xiaohan He, Bin Liu. Advances in Adhesive Drug Delivery for Recurrent Aphthous Ulcers[J]. Chinese Journal of Stomatological Continuing Education, 2025, 28(6): 393-397.

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复发性阿弗他溃疡粘附性药物递送研究进展

Advances in Adhesive Drug Delivery for Recurrent Aphthous Ulcers

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