光动力疗法辅助治疗牙周炎的研究进展

doi:10.12337/zgkqjxjyzz.2025.06.004

中国口腔医学继续教育杂志 ›› 2025, Vol. 28 ›› Issue (6): 398-404.DOI: 10.12337/zgkqjxjyzz.2025.06.004

光动力疗法辅助治疗牙周炎的研究进展

谭荆红^1,3, 邱才卿², 郭威^3,*

¹滨州医学院口腔医学院;
²滨州医学院附属烟台口腔医院牙周科;
³滨州医学院附属烟台口腔医院牙体牙髓科·激光综合门诊

出版日期:2025-11-30 发布日期:2025-11-30
通讯作者: ^*郭威,联系方式：0535-6020127,电子邮箱：Email：xyd_gw@163.com,通讯地址：山东省烟台市莱山区逛荡河东路1866号,264000
基金资助:
烟台市科技创新发展计划（项目编号：2023YD056）

Research Progress on Photodynamic Therapy as an Adjuvant Treatment for Periodontitis

Jinghong Tan^1,3, Caiqing Qiu², Wei Guo^3,*

¹School of Stomatology, Binzhou Medical University, Yantai, Shandong Province, P.R. China;
²Department of Periodontics, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, Shandong Province, P.R. China;
³Department of Endodontics & Laser Clinic, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, Shandong Province, P.R. China

Online:2025-11-30 Published:2025-11-30
Contact: Wei Guo. Tel: 0535-6020127. Email: xyd_gw@163.com. Address: 1866 Guandanghe East Road, Laishan District, Yantai 264008, Shandong Province, P.R. China.
Supported by:
Yantai Science and Technology Innovation Development Program (No.2023YD056)

摘要/Abstract

摘要： 光动力疗法（photodynamic therapy,PDT）是一种新型的抗菌方法,该技术是通过产生细胞毒性活性氧破坏病原菌的DNA和细胞膜,达到治疗的目的。因其具有不易产生耐药性、低毒、微创性等优点,近年来,大量学者对PDT辅助治疗牙周炎的效果开展了一系列的研究。本文就PDT辅助治疗牙周炎在工作原理、作用机制、临床疗效及特殊人群应用等方面的研究进展,以及新型光敏剂开发、优化纳米递送系统、治疗设备革新、个体化治疗策略实施和上转换纳米粒子应用等创新应用作一综述,为牙周炎的治疗提供新的思路。

关键词: 牙周炎, 光动力疗法, 辅助治疗, 临床疗效, 特殊人群应用

Abstract: Photodynamic therapy (PDT) is a new type of antibacterial method. This technology works by generating cytotoxic reactive oxygen species to destroy the DNA and cell membranes of pathogenic bacteria, achieving the purpose of treatment. Due to its advantages of being less likely to develop drug resistance and having low toxicity and minimal invasiveness, in recent years, a large number of scholars have conducted a series of studies on the effectiveness of PDT as an adjuvant treatment for periodontitis. This article reviews the research progress of PDT in the adjunctive treatment of periodontitis, including its working principle, mechanism of action, clinical efficacy and application in special populations, as well as innovative applications such as the development of new photosensitizers, optimized nanodelivery systems, improvement of therapeutic devices, implementation of individualized treatment strategies and application of up-conversion nanoparticles, offering new ideas for the treatment of periodontitis.

Key words: periodontitis, photodynamic therapy, adjuvant therapy, clinical efficacy, special population applications

谭荆红, 邱才卿, 郭威. 光动力疗法辅助治疗牙周炎的研究进展[J]. 中国口腔医学继续教育杂志, 2025, 28(6): 398-404.

Jinghong Tan, Caiqing Qiu, Wei Guo. Research Progress on Photodynamic Therapy as an Adjuvant Treatment for Periodontitis[J]. Chinese Journal of Stomatological Continuing Education, 2025, 28(6): 398-404.

参考文献

[1] Nie M, Zhang P, Pathak JL, et al.Photodynamic therapy in periodontitis: A narrative review[J]. Photodermatol Photoimmunol Photomed, 2024, 40(1):e12946.
[2] 孟焕新. 牙周病学[M].第5版.北京:人民卫生出版社, 2020:1.
[3] 马玉,左玉,张鑫.光动力疗法辅助治疗牙周炎治疗效果的Meta分析[J].国际口腔医学杂志, 2022, 49(03):305-316.
[4] Cobb CM, Sottosanti JS.A re-evaluation of scaling and root planning[J]. J Periodontol, 2021, 92(10):1370-1378.
[5] WangYY, Chen YK, Hu CS, et al. MAL-PDT inhibits oral precan cerous cells and lesions via autophagic cell death[J].Oral Dis, 2019, 25(3):758-771.
[6] Wainwright M, Maisch T, Nonell S, et al.Photoantimicrobials-are we afraid of the light[J]. Lancet Infect Dis, 2017, 17(2):e49-e55.
[7] Sales LS, Miranda ML, de Oliveira AB, et al. Effect of the technique of photodynamic therapy against the main microorganisms responsible for periodontitis: A systematic review of in-vitro studies[J]. Arch Oral Biol, 2022, 138:105425.
[8] Bourbour S, Darbandi A, Bostanghadiri N, et al.Effects of Antimicrobial Photosensitizers of Photodynamic Therapy (PDT) to Treat Periodontitis[J]. Curr Pharm Biotechnol, 2024, 25(10):1209-1229.
[9] Karrabi M, Baghani Z, Assarzadeh H.Gingival crevicular fluid level of tumor necrosis factor-alpha as a valuable biomarker for estimation of the efficacy of adjunctive antimicrobial photodynamic therapy in stage II-IV periodontitis: a systematic review and meta-analysis[J]. Lasers Med Sci, 2024, 39(1):301.
[10] Kharkar VV, Kolte AP, Kolte RA, et al.Influence of Adjunctive Photodynamic Therapy on Interleukin-6, Interleukin-8, and Interleukin-10 Gingival Crevicular Fluid Levels in Chronic Periodontitis-A Randomized Controlled Trial[J]. Contemp Clin Dent, 2021, 12(3):235-240.
[11] Jiang C, Yang W, Wang C, et al.Methylene Blue-Mediated Photodynamic Therapy Induces Macrophage Apoptosis via ROS and Reduces Bone Resorption in Periodontitis[J]. Oxid Med Cell Longev, 2019, 2019:1529520.
[12] Sun Y, Sun X, Li X, et al.A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization[J]. Biomaterials, 2021, 268:120614.
[13] Garcia VG, Miessi DMJ, da Rocha TE, et al. Shedding Light on the Therapeutic Efficiency of Oxygen-Releasing Gel and Photodynamic Therapy as Adjuvants in the Treatment of Experimental Periodontitis[J]. Photobiomodul Photomed Laser Surg, 2025, 43(4):159-172.
[14] Nuernberg MAA, Wainwright M, Miessi DMJ, et al.Effects of butyl toluidine blue photosensitizer on antimicrobial photodynamic therapy for experimental periodontitis treatment in rats[J]. Photodiagnosis Photodyn Ther, 2020, 31:101868.
[15] Losev FF, Krechina EK, Ivanova EV, et al.Primenenie fotodinamicheskoi terapii v kompleksnom lechenii khronicheskogo generalizovannogo parodontita srednei stepeni[The use of photodynamic therapy in the complex treatment of chronic generalized moderate periodontitis] [J]. Stomatologiia(Mosk), 2023, 102(2):11-15.
[16] Mahdizade Ari M, Amirmozafari N, Atieh Darbandi, et al.Effectiveness of photodynamic therapy on the treatment of chronic periodontitis: a systematic review during 2008-2023[J]. Front Chem. 2024, 12:1384344.
[17] Rodrigues RD, Araujo NS, Filho JMP, et al.Photodynamic therapy as adjunctive treatment of single-rooted teeth in patients with grade C periodontitis: A randomized controlled clinical trial[J]. Photodiagnosis Photodyn Ther, 2023, 44:103776.
[18] 范雅丹, 束蓉, 程岚, 等. 光动力疗法辅助治疗Ⅲ期、Ⅳ期牙周炎的临床效果评价[J]. 上海口腔医学, 2022, 31(05):501-506.
[19] Villafuerte KRV, Martinez CJH, Palucci Vieira LH, et al.Benefits of Antimicrobial Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Treatment in Smokers with Periodontitis: A Systematic Review and Meta-Analysis[J]. Medicina (Kaunas), 2023, 59(4):684.
[20] Nedumaran N, Rajasekar A.Efficacy of Rose Bengal-Mediated Antimicrobial Photodynamic Therapy as an Adjunct to Scaling and Root Planing on Clinical and Microbiological Parameters in the Management of Chronic Periodontitis: A Single-Blinded, Randomized Controlled Clinical Trial[J]. Photobiomodul Photomed Laser Surg, 2024, 42(8):561-567.
[21] Nie M, Huang P, Peng P, et al.Efficacy of photodynamic therapy as an adjunct to scaling and root planing on clinical parameters and microbial composition in subgingival plaque of periodontitis patients: A split-mouth randomized clinical trial[J]. J Periodontol, 2024, 95(6):535-549.
[22] Muzaheed, Acharya S, Hakami AR, et al. Effectiveness of single versus multiple sessions of photodynamic therapy as adjunct to scaling and root planing on periodontopathogenic bacteria in patients with periodontitis[J]. Photodiagnosis Photodyn Ther, 2020, 32:102035.
[23] 刘明军,宋莉,邹海啸,等.光动力抗菌疗法治疗牙周炎的研究进展[J].中国激光医学杂志, 2017, 26(4): 210-215.
[24] AlAhmari F, Ahmed HB, Al-Kheraif AA, et al. Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial[J]. Photodiagnosis Photodyn Ther, 2019, 25:247-252.
[25] Capodiferro S.Comment on “Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis”[J]. Lasers Med Sci, 2018, 33(6):1409.
[26] Ding R, Liu X, Zhao X, et al.Membrane-anchoring selenophene viologens for antibacterial photodynamic therapy against periodontitis via restoring subgingival flora and alleviating inflammation. Biomaterials, 2024, 307:122536.
[27] de Freitas LM, Calixto GM, Chorilli M, et al. Polymeric Nanoparticle-Based Photodynamic Therapy for Chronic Periodontitis in Vivo[J]. Int J Mol Sci, 2016, 17(5):769.
[28] Liang S, Li MH, Qi ML, et al.Reactive Oxygen Species-Responsive Pillararene-Embedded Covalent Organic Frameworks with Amplified Antimicrobial Photodynamic Therapy for the Targeted Elimination of Periodontitis Pathogens[J]. Nano Lett, 2024, 24(43):13708-13717.
[29] Garcia de Carvalho G, Maquera-Huacho PM, Silva Pontes C, et al. Chlorin-e6 conjugated to the antimicrobial peptide LL-37 loaded nanoemulsion enhances photodynamic therapy against multi-species biofilms related to periodontitis[J]. Photodiagnosis Photodyn Ther, 2023, 43:103725.
[30] Tonon CC, de Souza Rastelli AN, Bodahandi C, et al. Superhydrophobic Tipped Antimicrobial Photodynamic Therapy Device for the In Vivo Treatment of Periodontitis Using a Wistar Rat Model[J]. ACS Appl Mater Interfaces, 2023, 15(43):50083-50094.
[31] Coradi Tonon C, de Souza Rastelli AN, Bodahandi C, et al. Effect of treatment frequency on the efficacy of superhydrophobic antimicrobial photodynamic therapy of periodontitis in a wistar rat model[J]. Photochem Photobiol, 2025, 101(3):592-608.
[32] Pakarinen S, Saarela RKT, Välimaa H, et al.Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)-Three-Month Interim Results[J]. Dent J(Basel), 2022, 10(11):206.
[33] de Almeida JM, Matheus HR, Sendão Alves BE, et al. Evaluation of antimicrobial photodynamic therapy with acidic methylene blue for the treatment of experimental periodontitis[J]. PLoS One, 2022, 17(2):e0263103.
[34] Al-Kheraif AA, Alshahrani OA, Al-Shehri AM, et al.Chloro-aluminum phthalocyanine-mediated photodynamic therapy in the treatment of stage-II chronic periodontitis among smokers[J]. Photodermatol Photoimmunol Photomed, 2022, 38(6):582-590.
[35] Qi M, Li X, Sun X, et al.Novel nanotechnology and near-infrared photodynamic therapy to kill periodontitis-related biofilm pathogens and protect the periodontium[J]. Dent Mater, 2019, 35(11):1665-1681.
[36] Shi E, Bai L, Mao L, et al.Self-assembled nanoparticles containing photosensitizer and polycationic brush for synergistic photothermal and photodynamic therapy against periodontitis[J]. J Nanobiotechnology, 2021, 19(1):413.
[37] Annaji S, Sarkar I, Rajan P, et al. Efficacy of Photodynamic Therapy and Lasers as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis - A Clinical and Microbiologic Short Term Study[J]. J Clin Diagn Res, 2016, 10(2):ZC08-ZC12.
[38] Skalerič E, Petelin M, Gašpirc B.Antimicrobial photodynamic therapy in treatment of aggressive periodontitis (stage III, grade C periodontitis): A comparison between photodynamic therapy and antibiotic therapy as an adjunct to non-surgical periodontal treatment[J]. Photodiagnosis Photodyn Ther, 2023, 41:103251.
[39] Al-Kheraif AA, Alshahrani OA, Al-Shehri AM, et al.Antimicrobial photodynamic therapy using chloro-aluminum phthalocyanine for treating advanced stage-III periodontitis in smoking patients[J]. Photodermatol Photoimmunol Photomed, 2022, 38(6):591-599.
[40] Gualberto EC Jr, Theodoro LH, Longo M, et al.Antimicrobial photodynamic therapy minimizes the deleterious effect of nicotine in female rats with induced periodontitis[J]. Lasers Med Sci, 2016, 31(1):83-94.
[41] Michalowicz BS, Pihlstrom BL, Hodges JS.Diabetes and periodontitis[J].J Clin Periodontol, 2024, 51(9):1252-1253.
[42] da Silva-Junior PGB, Abreu LG, Costa FO, et al. The effect of antimicrobial photodynamic therapy adjunct to non-surgical periodontal therapy on the treatment of periodontitis in individuals with type 2 diabetes mellitus: A systematic review and meta-analysis[J]. Photodiagnosis Photodyn Ther, 2023, 42:103573.
[43] Cláudio MM, Nuernberg MAA, Rodrigues JVS, et al.Effects of multiple sessions of antimicrobial photodynamic therapy (aPDT) in the treatment of periodontitis in patients with uncompensated type 2 diabetes: A randomized controlled clinical study[J]. Photodiagnosis Photodyn Ther, 2021, 35:102451.
[44] Elsadek MF, Ahmed BM, Alkhawtani DM, et al.A comparative clinical, microbiological and glycemic analysis of photodynamic therapy and Lactobacillus reuteri in the treatment of chronic periodontitis in type-2 diabetes mellitus patients[J]. Photodiagnosis Photodyn Ther, 2020, 29:101629.
[45] Nunes GP, de Oliveira Alves R, Ragghianti MHF, et al. Antimicrobial photodynamic therapy in the nonsurgical treatment of periodontitis in patients with HIV infection: a systematic review and meta-analysis[J]. Lasers Med Sci, 2024, 39(1):155.
[46] Niazi FH, Koppolu P, Tanvir SB, et al.Clinical efficacy of photodynamic therapy in the treatment of necrotizing ulcerative periodontitis among HIV seropositive patients: A randomized controlled clinical trial[J]. Photodiagnosis Photodyn Ther, 2020, 29:101608.
[47] Elsadek MF, Farahat MF.Effectiveness of photodynamic therapy as an adjunct to periodontal scaling for treating periodontitis in geriatric patients[J]. Eur Rev Med Pharmacol Sci, 2022, 26(6):1832-1838.
[48] Pillusky FM, Barcelos RCS, Vey LT, et al.Antimicrobial photodynamic therapy with photosensitizer in ethanol improves oxidative status and gingival collagen in a short-term in periodontitis[J]. Photodiagnosis Photodyn Ther, 2017, 19:119-127.

光动力疗法辅助治疗牙周炎的研究进展

Research Progress on Photodynamic Therapy as an Adjuvant Treatment for Periodontitis

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