Clinical Observation of Alveolar Bone Graft with Autogenous Cortical Bone Combined with Calcium Phosphate Cement Powder Containing Recombinant Human Bone Morphogenetic Protein-2

doi:10.12337/zgkqjxjyzz.2024.02.002

Chinese Journal of Stomatological Continuing Education ›› 2024, Vol. 27 ›› Issue (2): 124-131.DOI: 10.12337/zgkqjxjyzz.2024.02.002

Previous Articles Next Articles

Clinical Observation of Alveolar Bone Graft with Autogenous Cortical Bone Combined with Calcium Phosphate Cement Powder Containing Recombinant Human Bone Morphogenetic Protein-2

Xinran Zhao^#, Jiahui Xie^#, Zuyin Yu, Xuefei Pang, Ming Cai^*

Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, No. 639 Zhizaoju Road, Huangpu District, Shanghai , P.R. China

Online:2024-03-31 Published:2024-09-23
Contact: Ming Cai. Tel: 021-23271699-5655. Email: zidanecm500@126.com. Address: No.639 Zhizaoju Road, Huangpu District, Shanghai 200011, P.R. China.
About author:^#These two authors contributed equally to this work.
Supported by:
Osteogenic Effect of Minimally Invasive Unilateral Alveolar Cleft Repair Using Sandwich Like Bone Graft: A randomized controlled study, Shanghai’s Top Priority Research Center, Grant/Award (No.2022ZZ01017) CAMS Innovation Fund for Medical Sciences (CIFMS), Grant/Award (No.2019-I2M-5-037) National Clinical Research Center for Oral Diseases (Shanghai Ninth People’s Hospital) Clinical Research Project for Oral Medicine, Grant/Award (No. NCRCO202328)

Abstract

Abstract: Objective: To summarize the osteogenic effect of monocortical mandibular bone combined with calcium phosphate cement (CPC) powder containing recombinant human bone morphogenetic protein-2 (rhBMP-2) in alveolar bone graft. Methods: Patients with alveolar cleft treated by the above methods from December 2020 to November 2021 were reviewed, and the bone resorption and complications were analyzed. Results: A total of 8 cases were included, the average bone resorption rate was 28.88%. One case had wound dehiscence, and the curative effect was still good after treatment. One case suffered from wound dehiscence and infection 2 weeks after operation. The CT scan at 6 months after operation indicated that the graft bone was not continuous with the surrounding bone. At 8 months after operation, the bone block was discharged from the dehiscence. Conclusions: The effect of monocortical mandibular bone combined with CPC powder containing rhBMP-2 in repairing alveolar cleft was acceptable with lower bone absorption rate, higher new bone density, less trauma, and thus valuable clinical application.

Key words: monocortical mandible bone, bone graft, recombinant human bone morphogenetic protein-2, calcium phosphate cement, alveolar bone graft

Xinran Zhao, Jiahui Xie, Zuyin Yu, Xuefei Pang, Ming Cai. Clinical Observation of Alveolar Bone Graft with Autogenous Cortical Bone Combined with Calcium Phosphate Cement Powder Containing Recombinant Human Bone Morphogenetic Protein-2[J]. Chinese Journal of Stomatological Continuing Education, 2024, 27(2): 124-131.

References

[1] Leal CR, de Carvalho RM, Ozawa TO, et al. Outcomes of Alveolar Graft With Rhbmp-2 in CLP: Influence of Cleft Type and Width, Canine Eruption, and Surgeon[J]. Cleft Palate Craniofac J. 2019; 56(3):383-389.
[2] 唐璟, 宋庆高. 影响牙槽突裂植骨术效果的相关因素[J]. 中国临床研究, 2021, 34(4):554-557.
[3] Brudnicki A, Rachwalski M, Wiepszowski Ł, et al.Secondary alveolar bone grafting in cleft lip and palate: A comparative analysis of donor site morbidity in different age groups[J]. J Craniomaxillofac Surg. 2019; 47(1):165-169.
[4] 张柯佳, 严斌, 刘璐玮, 等. 牙槽突裂植骨术后移植骨桥的三维纵向变化研究[J]. 中华口腔正畸学杂志, 2020, 27(4):216-221.
[5] 任战平, 陈志文, 陶永炜, 等. 基于CBCT的牙槽突裂植骨的三维定量研究[J]. 临床口腔医学杂志, 2014, 30(9):534-536.
[6] Enemark H, Jensen J, Bosch C.Mandibular bone graft material for reconstruction of alveolar cleft defects: long-term results[J]. Cleft Palate Craniofac J. 2001; 38(2):155-163.
[7] Shirzadeh A, Rahpeyma A, Khajehahmadi S.A Prospective Study of Chin Bone Graft Harvesting for Unilateral Maxillary Alveolar Cleft During Mixed Dentition[J]. J Oral Maxillofac Surg. 2018; 76(1):180-188.
[8] Hoppenreijs TJ, Nijdam ES, Freihofer HP.The chin as a donor site in early secondary osteoplasty: a retrospective clinical and radiological evaluation[J]. J Craniomaxillofac Surg. 1992; 20(3):119-124.
[9] Kilinc A, Saruhan N, Ertas U, et al.An Analysis of Mandibular Symphyseal Graft Sufficiency for Alveolar Cleft Bone Grafting[J]. J Craniofac Surg. 2017; 28(1):147-150.
[10] Dik EA, de Ruiter AP, van der Bilt A, et al. Effect on the contour of bone and soft tissue one year after harvesting chin bone for alveolar cleft repair[J]. Int J Oral Maxillofac Surg. 2010; 39(10):962-967.
[11] Mikoya T, Inoue N, Matsuzawa Y, et al.Monocortical mandibular bone grafting for reconstruction of alveolar cleft[J]. Cleft Palate Craniofac J. 2010; 47(5):454-468.
[12] Linderup BW, Cattaneo PM, Jensen J, et al.Mandibular Symphyseal Bone Graft for Reconstruction of Alveolar Cleft Defects: Volumetric Assessment With Cone Beam Computed Tomography 1-Year Postsurgery[J]. Cleft Palate Craniofac J. 2016; 53(1):64-72.
[13] Saaby M, Norholt SE, Küseler A, et al.Day Care Surgery for Unilateral Alveolar Bone Grafting of Residual Clefts With Mandibular Symphyseal Bone-A Prospective Questionnaire Study[J]. Cleft Palate Craniofac J. 2022; 59(2):216-221.
[14] Guo W, Lu B, Liu F, et al.Comprehensive repair of the alveolar cleft using cortical and cancellous bone layers: A retrospective study[J]. J Craniomaxillofac Surg. 2024; 52(3):310-315.
[15] Cho AR, Kim HK, Kwon JY, et al.The incorporation of platelet-rich plasma into calcium phosphate cement enhances bone regeneration in osteoporosis[J]. Pain Physician. 2014; 17(6):E737-745.
[16] 欧梁, 孔德忠, 徐道情, 等. 比较聚甲基丙烯酸甲酯与自固化磷酸钙骨水泥在椎体成形中应用效果的Meta分析[J]. 中国组织工程研究, 2022, 26(4):649-656.
[17] Kim JK, Koh YD, Kook SH.Effect of calcium phosphate bone cement augmentation on volar plate fixation of unstable distal radial fractures in the elderly[J]. J Bone Joint Surg Am. 2011; 93(7):609-614.
[18] 李万韬, 王天珏, 李元, 等. 自固化磷酸钙复合材料辅助即刻种植的实验研究[J]. 实用口腔医学杂志, 2018, 34(3):303-307.
[19] 甘欣怡, 马坚, 于丽丽, 等. 生物材料在牙槽突裂治疗中的应用[J]. 宁夏医学杂志, 2023, 45(2):190-192.
[20] Pountos I, Georgouli T, Henshaw K, et al.The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone[J]. J Orthop Trauma. 2010; 24(9):552-556.
[21] 田永福, 刘继权, 胡攸水, 等. 载重组人BMP-2磷酸钙联合载抗生素磷酸钙人工骨治疗慢性骨髓炎伴骨缺损的临床研究[J].中国修复重建外科杂志, 2021, 35(05):573-578.
[22] 王炜, 玛依拉.吾甫尔, 阿不都赛米.艾买提, 等. 重组人类骨形态蛋白2复合自固化磷酸钙材料在体内的血管化[J]. 中国组织工程研究与临床康复, 2011, 15(29):5359-5362.
[23] Xiao WL, Jia KN, Yu G, et al.Outcomes of bone morphogenetic protein-2 and iliac cancellous bone transplantation on alveolar cleft bone grafting: A meta-analysis[J]. J Plast Reconstr Aesthet Surg. 2020; 73(6):1135-1142.
[24] Shen H, Li L, Zhang C, et al. The strategy of composite grafting with BMP2-Loaded calcium phosphate cements and autogenous bone for alveolar cleft reconstruction[J]. Front Physiol.2022; 27; 13:1023772.
[25] 朱洪平. 美国唇腭裂及颅面异常诊疗指南演变和解读[J]. 中国口腔医学继续教育杂志, 2023, 26(3):174-178.
[26] 张勇, 杨育生, 吴忆来, 等. 牙槽突裂植骨吸收率的测量分析[J]. 上海口腔医学, 2012, 21(3):308-311.
[27] Nagashima H, Sakamoto Y, Ogata H, et al.Evaluation of bone volume after secondary bone grafting in unilateral alveolar cleft using computer-aided engineering[J]. Cleft Palate Craniofac J. 2014; 51(6):665-668.
[28] Guo W, Lu B, Liu F,et al.Comprehensive repair of the alveolar cleft using cortical and cancellous bone layers: A retrospective study.[J] Craniomaxillofac Surg. 2024; 52(3):310-315.
[29] Mathew P, Varun Menon P. Cortical Bone Graft and GTR Membrane as “Ceiling Effect” in Alveolar Bone Grafting. J Maxillofac Oral Surg.2018 Jun; 17(2):260-263.

Clinical Observation of Alveolar Bone Graft with Autogenous Cortical Bone Combined with Calcium Phosphate Cement Powder Containing Recombinant Human Bone Morphogenetic Protein-2

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 0

Recommended Articles

Metrics

Comments