Effects of Anesthetics on Immune Function in Patients with Tumor

doi:10.12337/zgkqjxjyzz.2023.06.010

Chinese Journal of Stomatological Continuing Education ›› 2023, Vol. 26 ›› Issue (6): 474-478.DOI: 10.12337/zgkqjxjyzz.2023.06.010

Previous Articles Next Articles

Effects of Anesthetics on Immune Function in Patients with Tumor

Lili Huang^1,2, Tiejun Zhang^1,2,*

¹The State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University;
²Department of Anesthesiology, School and Hospital of Stomatology, Wuhan University

Online:2023-11-30 Published:2024-03-13
Contact: ^*Tiejun Zhang. Tel: 027-87686242. Email: ztj@whu.edu.cn. Address: No.237, Luoyu Road, Hongshan District, Wuhan 430079, Hubei Province, P.R.China.
Supported by:
Hubei Natural Science Foundation(No:2022CFB065)

Abstract

Abstract: The immune system is classically divided into innate and adaptive components, which play an important role in the host’s resistance to pathogens and tumor invasion. A large number of studies have attempted to understand the effects of anesthetics on immune function. The most commonly used anesthetic agents were chosen in this review including volatile agents, intravenous agents, opioids, and local anesthetics. Each has unique effect on the immune system. Specific treatment strategies need to be developed to improve short and long term surgical outcomes for patients with malignant tumors.

Key words: anesthetics, immune, tumor patients, tumor metastasis, surgery

Lili Huang, Tiejun Zhang. Effects of Anesthetics on Immune Function in Patients with Tumor[J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(6): 474-478.

References

[1] Onuma AE, Zhang HJ, Gil L, et al.Surgical stress promotes tumor progression: a focus on the impact of the immune response[J]. J Clin Med. 2020; 9(12):4096.
[2] Perera SK, Jacob S, Wilson BE, et al.Global demand for cancer surgery and an estimate of the optimal surgical and anaesthesia workforce between 2018 and 2040: a population-based modelling study[J]. Lancet Oncol. 2021; 22(2):182-189.
[3] Ackerman RS, Luddy KA, Icard BE, et al.The Effects of Anesthetics and Perioperative Medications on Immune Function: A Narrative Review[J]. Anesth Analg. 2021; 133(3):676-689.
[4] Pandya PH, Murray ME, Pollok KE, et al.The immune system in cancer pathogenesis: potential therapeutic approaches[J]. J Immunol Res. 2016; 4273943.
[5] Wang L, Shen Y.Imbalance of circulating T-lymphocyte subpopulation in gastric cancer patiens correlated with performance status[J]. Clin Lab. 2013; 59(3-4):429-433.
[6] 王俞, 崔书中. 恶性肿瘤患者的免疫功能状态及免疫治疗研究进展[J]. 中国肿瘤临床, 2014, 41(13):876-879.
[7] Deng X, Terunuma H.Harnessing NK Cells to Control Metastasis[J].Vaccines (Basel). 2022; 10(12):2018.
[8] Yap A, Lopez-Olivo MA, Dubowitz J, et al.Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia[J]. Can J Anaesth. 2019; 66(5):546-561.
[9] Koutsogiannaki S, Bernier R, Tazawa K, et al.Volatile anesthetic attenuates phagocyte function and worsens bacterial loads in wounds[J]. J Surg Res. 2019; 233:323-330.
[10] Jing Y, Zhang Y, Pan R, et al.Effect of Inhalation Anesthetics on Tumor Metastasis[J]. Technol Cancer Res Treat. 2022; 21:15330338221121092.
[11] Loop T, Scheiermann P, Doviakue D, et al.Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway[J]. Anesthesiology. 2004; 101:710-721.
[12] Xia SH, Zhou D, Ge F, et al.Influence of Perioperative Anesthesia on Cancer Recurrence: from Basic Science to Clinical Practice[J]. Curr Oncol Rep. 2023; 25(2):63-81.
[13] Ma Z, Wang LZ, Cheng JT, et al. Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy[J]. Antioxid Redox Signal.2021, 20; 34(18):1484-1497.
[14] Huang H, Benzonana LL, Zhao H, et al.Prostate cancer cell malignancy via modulation of HIF-1alpha pathway with isoflflurane and propofol alone and in combination[J]. Br J Cancer. 2014; 111:1338-1349.
[15] Miklić Bublić M, Tonković D, Sakan S, et al.Effect of Inhalational Anesthetics on Acute Kidney Injury[J]. Acta Clin Croat. 2016; 55(3):464-468.
[16] Sahinovic MM, Struys MMRF, Absalom AR.Clinical Pharmacokinetics and Pharmacodynamics of Propofol[J]. Clin pharmacokinet. 2018; 57(12):1539-1558
[17] Zhou M, Dai J, Zhou Y, et al.Propofol improves the function of natural killer cells from the peripheral blood of patients with esophageal squamous cell carcinoma[J]. Exp Ther Med. 2018; 16(1):83-92.
[18] Xia SH, Zhou D, Ge F, et al.Influence of Perioperative Anesthesia on Cancer Recurrence: from Basic Science to Clinical Practice[J]. Curr Oncol Rep. 2023; 25(2): 63-81.
[19] Zhang T, Fan Y, Liu K, et al.Effects of different general anesthetic techniques on immune responses in patients undergoing surgery for tongue cancer[J]. Anaesth Intensive Care. 2014; 42:220-227.
[20] Oh CS, Park HJ, Piao L, et al.Expression Profiles of Immune Cells after Propofol or Sevoflurane Anesthesia for Colorectal Cancer Surgery: A Prospective Double-blind Randomized Trial[J]. Anesthesiology. 2022; 136(3):448-458.
[21] Gu L, Pan X, Wang C, et al.The benefits of propofol on cancer treatment: Decipher its modulation code to immunocytes[J]. Front Pharmacol. 2022; 13:919636.
[22] Wu ZF, Lee MS, Wong CS, et al.Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in colon cancer surgery[J]. Anesthesiology. 2018; 129(5):932-941.
[23] Enlund M, Berglund A, Andreasson K, et al.The choice of anesthetic-sevoflurane or propofol-and outcome from cancer surgery: a retrospective analysis[J]. Ups J Med Sci. 2014; 119:251-261.
[24] Lim A, Braat S, Hiller J, et al.Inhalational versus propofol based total intravenous anaesthesia: practice patterns and perspectives among Australasian anesthetists[J]. Anesth Intensive Care. 2018; 46:480-487.
[25] Wang K, Li C.Effects of dexmedetomidine on inflammatory factors, T lymphocyte subsets and expression of NF-κB in peripheral blood mononuclear cells in patients receiving radical surgery of colon carcinoma[J]. Oncol Lett. 2018; 15(5):7153-7157.
[26] Yang XH, Bai Q, Lv MM, et al.Effect of dexmedetomi-dine on immune function of patients undergoing radical mastectomy: a double blind and placebo control study[J]. Eur Rev Med Pharmacol Sci. 2017; 21(5):1112-1116.
[27] Lee S.Dexmedetomidine: present and future directions[J]. Korean J Anesthesiol. 2019; 72(4):323-330.
[28] Cole SW, Nagaraja AS, Lutgendorf SK, et al.Sympathetic nervous system regulation of the tumour microenvironment[J]. Nat Rev Cancer. 2015; 15:563-572.
[29] Liu Z, Wang Y, Wang Y, et al.Dexmedetomidine attenuates inflammatory reaction in the lung tissues of septic mice by activating cholinergic anti-inflammatory pathway[J]. Int Immunopharmacol. 2016; 35:210-216.
[30] Wang K, Wu M, Xu J, et al.Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis[J]. Br J Anaesthesia. 2019; 123(6):777-794.
[31] Huang L, Qin C, Wang L, et al.Effects of dexmedeto-midine on immune response in patients undergoing radical and reconstructive surgery for oral cancer[J]. Oncol Lett. 2021; 21(2):106.
[32] Eisenstein TK.The role of opioid receptors in immune system function[J]. Front Immunol. 2019; 10:2904.
[33] Plein LM, Rittner HL.Opioids and the immune system-friend or foe[J]. Br J Pharmacol. 2018; 175:2717-2725.
[34] Zhao L, Teng L, Zhang W, et al.Dose of intra-operative opioids has no impact on recurrence or survival in primary liver cancer[J]. Cancer Med. 2022; 11(24):4927-4934.
[35] Cronin AJ, Aucutt-Walter NM, Budinetz T, et al.Low-dose remifentanil infusion does not impair natural killer cell function in healthy volunteers[J]. Br J Anaesth. 2003; 91:805-809.
[36] Moyano J, Aguirre L.Opioids in the immune system: from experimental studies to clinical practice[J]. Rev Assoc Med Bras. 2019; 65:262-269.
[37] Longhini F, Bruni A, Garofalo E, et al.Anesthetic strategies in oncological surgery: not only a simple sleep, but also impact on immunosuppression and cancer recurrence[J]. Cancer Manag Res. 2020; 12:931-940.
[38] Zhang D, Jiang J, Liu J, et al.Effects of Perioperative Epidural Analgesia on Cancer Recurrence and Survival[J]. Front Oncol. 2022; 11:798435.
[39] Gu C, Wang L, He Y, et al.Effect of Local Versus General Anesthesia in Breast-Conserving Surgery on Cancer Recurrence and Cost[J]. Cancer Control. 2022; 29:10732748221083078.

Effects of Anesthetics on Immune Function in Patients with Tumor

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Recommended Articles

Metrics

Comments

[1]	Yanli Zhang, Zhoupeng Zheng. Research Progress of Postoperative Nausea and Vomiting [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(6): 438-441.
[2]	Xiaodong Wang, Xudong Yang, Yun Liu. Application of Trigeminal Nerve Block in Oral and Maxillofacial Surgery [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(6): 449-453.
[3]	Qiang Li, Xiao Shao, Liping Zhao. Multidisciplinary Treatment of Complicated Dental Trauma of Upper Anterior Teeth: A Case Report [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(5): 361-375.
[4]	Yanjie Bai, Xiao Wang, Yang Lu, Han Zhang, Wei Liu, Ning Ma. Multidisciplinary Management of Traumatized Periapical Lesions of Anterior Teeth: An 8-year Follow-up Case Report [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(5): 376-386.
[5]	Baoquan Fan, Xin Yang, Jiao Wang, Zhige Li. Clinical Diagnosis and Treatment of Prolapse Dislocation of Young Permanent Teeth: a Case Report [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(5): 403-410.
[6]	Li Peng, Na An, Zuhua Wang, Wenshu Ge, Tongkai Xu. Fixed Bridge Restoration after Apical Surgery for A Bridge Abutment Tooth: A Case Report [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(4): 264-272.
[7]	Zhanyi Gao, Yanjie Bai, Jingqi Wang, Shiqi Zou, Min Feng, Xiao Wang. Comprehensive Dental Care of Stage IV Grade C Periodontitis: A Case Report [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(4): 294-307.
[8]	Jiali Chen, Ni Zeng, Chao Yang, Qian Zhen, Bing Shi, Hanyao Huang. Research progress on surgical training with simulator for cleft palate [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(3): 166-173.
[9]	Haiyan Qiu, Jingting Yu. Periodontal regenerative surgery combined with orthodontic movement for the treatment of vertical bone defects [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(1): 6-11.
[10]	Tianyuan Li, TongxinZhu, Jindong Chen, Bin Chen, Fuhua Yan. Management of impacted tooth during orthodontic treatment: a case report [J]. Chinese Journal of Stomatological Continuing Education, 2023, 26(1): 39-44.