Abstract: Objectives: This case reported the use of sagittal-guidance Twin-block appliance (SGTB) in the treatment of a patient with growth modification therapy. Diagnosis and Treatment: Following an accurate diagnosis and the patient’s informed consent, we protruded the mandible forward, expanded the upper arch and slightly aligned and retracted the maxillary front teeth using an adhesive SGTB. The brackets were bonded to finish fixed orthodontic treatment after the SGTB was removed. Results: The overall treatment time was 22 months. Mandibular growth in conjunction with dental movement and alveolar bone remodeling contributed to the favorable skeletal and dental relationships and soft tissue profile, with no relapse after three and a half years of follow-up. Conclusions: Adhesive SGTB is appropriate for patients reaching the end of maxillofacial growth peak. Growth modification therapy may also be tried on patients who have passed the peak of growth if it is expected to be beneficial to them.

Key words: sagittal-guidance Twin-block appliance, Twin-block appliance, growth modification therapy, early orthodontic treatment, skeletal class Ⅱ malocclusion;