A Randomized Controlled Clinical Study of Concentrated Growth Factor for Extraction of Mandibular Lower Impacted Third Molars

doi:10.12337/zgkqjxjyzz.2025.03.007

Chinese Journal of Stomatological Continuing Education ›› 2025, Vol. 28 ›› Issue (3): 158-165.DOI: 10.12337/zgkqjxjyzz.2025.03.007

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A Randomized Controlled Clinical Study of Concentrated Growth Factor for Extraction of Mandibular Lower Impacted Third Molars

Jun Ma^1,2,3, Le Bai^1,2, Xin Yang^1,2, Hao Cui^1,2, Sijia Na^1,2, Junbo Tu^1,2, Xiang Liang^1,2,*

¹Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi’an, Shaanxi Province, P.R. China;
²Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Xi’an, Shaanxi Province, P.R. China;
³Oral and Maxillofacial Surgery Outpatient Department, Xining Stomatological Hospital, Xining, Qinghai Province, P.R. China

Online:2025-05-31 Published:2025-05-31
Contact: Xiang Liang. Tel: 029-87215336. Email: 1529643062@qq.com. Address: No. 98, West 5th Road, Xincheng District, Xi’an 710004, Shaanxi Province, P.R. China.
Supported by:
Open Research Project of Shaanxi Provincial Clinical Research Center for Dento-Maxillofacial Diseases (No.2021YHJB08); The Research and Innovation Team for Oral and Maxillofacial Surgery at the Shaanxi Provincial Health and Wellness Commission (No.2024TD-19)

Abstract

Abstract: Objective: To investigate the effect of concentrated growth factor (CGF) on the relief of complications and the healing and repair of soft and hard tissue after extraction of lower mandibular impacted third molar. Methods: Fifty patients with lower impacted third molars were randomly divided into experimental group and control group. Postoperative complications pain, swelling and soft tissue healing were compared at 1, 3 and 7 days after surgery, and the second molar pocket and alveolar bone tissue healing were compared 3 months later. Results: The wound healing index of experimental group was better than that of control group 7 days after operation (P<0.01). CGF alleviated local swelling 1 and 3 days after operation (P<0.001), and there was no significant difference between CGF and CGF on day 7. There was no statistical significance in visual simulation scores on the first day after surgery (P=0.250), and experimental group were lower than those on the control group on the 3rd and 7th day after surgery (P=0.001). There were significant differences in alveolar ridge width and buccal-lingual wall height between experimental group and control group (P<0.001). Bone density in experimental group was significantly higher than that in control group. The improvement of periodontal pocket in experimental group was significantly different (P<0.001). Conclusions: Local application of CGF can effectively promote wound healing, relieve local swelling and pain, and promote tissue regeneration after the extraction of lower mandibular third molar.

Key words: impacted third molar in lower jaw, CGF, complications, tissue healing, tooth extraction

Jun Ma, Le Bai, Xin Yang, Hao Cui, Sijia Na, Junbo Tu, Xiang Liang. A Randomized Controlled Clinical Study of Concentrated Growth Factor for Extraction of Mandibular Lower Impacted Third Molars[J]. Chinese Journal of Stomatological Continuing Education, 2025, 28(3): 158-165.

References

[1] Xu F, Elayah SA, Ren J, et al.Precision Extraction of Lingual Mandibular Supernumerary Teeth Using Dynamic Navigation and High-Speed Handpieces: A Case Report[J]. Am J Case Rep, 2024, 25:e945262.
[2] Çakan KN, İpek İ.A Dual Approach to Third Molar Complexity: Correlating Fractal Analysis with the Pederson Difficulty Index-Non-Clinical Research Article[J]. BMC Oral Health, 2025, 25(1):1073.
[3] Troiano G, Laino L, Cicciù M, et al.Comparison of Two Routes of Administration of Dexamethasone to Reduce the Postoperative Sequelae After Third Molar Surgery: A Systematic Review and Meta-Analysis[J]. Open Dent J, 2018, 12(1):181-188.
[4] Jegadeesan V, Ponnaiyan D. Impact of Aprotinin- A Proteolytic Enzyme on Postsurgical Symptoms in Patients Undergoing Third Molar Surgeries[J]. J Clin Diagn Res, 2016, 10(1):ZC18-Z22.
[5] Askin Ekinci S, Kiristioglu Z B, Ates O, et al.Traditional vs. Orthodontic Extraction of Impacted Teeth Related to the Inferior Alveolar Nerve: A Randomized Control Trial[J]. BMC Oral Health, 2025, 25(1):1036.
[6] Chen L, Liu J, Guan M, et al.Growth Factor and Its Polymer Scaffold-Based Delivery System for Cartilage Tissue Engineering[J]. Int J Nanomedicine, 2020, 15:6097-6111.
[7] Xu F, Qiao L, Zhao Y, et al.The Potential Application of Concentrated Growth Factor in Pulp Regeneration: An in Vitro and in Vivo Study[J]. Stem Cell Res Ther, 2019, 10(1):134.
[8] Cerqueira PR, Vasconcelos BC, Bessa-Nogueira RV.Comparative study of the effect of a tube drain in impacted lower third molar surgery[J]. J Oral Maxillofac Surg, 2004, 62(1):57-61.
[9] 许哲欣, 崔啸尘, 房雅静, 等. 下颌阻生第三磨牙及周围解剖形态与垂直骨面型之间关系的CBCT研究[J]. 现代中西医结合杂志, 2023, 32(10):1385-1389.
[10] 郭祥, 周宏志, 王一名, 等. 牙槽骨位点保存方法与生物材料的研究进展[J]. 空军军医大学学报, 2024, 45(10):1191-1195.
[11] 文超举, 刘春影, 裴婷婷, 等. 3种不同压膜方法对浓缩生长因子膜细胞因子释放及降解的影响[J]. 口腔医学, 2019, 39(10):889-894.
[12] 柳宏志, 邹高峰, 王天祥, 等. 浓缩生长因子促进犬软组织损伤修复的实验研究[J]. 口腔颌面外科杂志, 2013, 23(1):28-31.
[13] Ozgul O, Senses F, Er N, et al.Efficacy of Platelet Rich Fibrin in the Reduction of the Pain and Swelling after Impacted Third Molar Surgery: Randomized Multicenter Split-Mouth Clinical Trial[J]. Head Face Med, 2015, 11:37.
[14] Liao Y, Fang Y, Zhu H, et al.Concentrated Growth Factors Promote hBMSCs Osteogenic Differentiation in a Co-Culture System With HUVECs[J]. Front Bioeng Biotechnol, 2022, 10:837295.
[15] Zhou W, Mao C, Shi G, et al.A Clinical Study on the Preservation of Pulp Sensitivity in Affected Teeth with Jaw Cysts Using Concentrated Growth Factor: A Retrospective Cross-Sectional Study[J]. Sci Rep, 2025, 15(1):19482.
[16] Ma F, Lin Y, Sun F, et al.The Impact of Autologous Concentrated Growth Factors on the Alveolar Ridge Preservation after Posterior Tooth Extraction: A Prospective, Randomized Controlled Clinical Trial[J]. Clin Implant Dent Relat Res, 2021, 23(4):579-592.
[17] Zhan L, Yang Y, Zhao X, et al.Clinical Outcomes of a Peri-Implant Keratinized Mucosa Augmentation Procedure Using Concentrated Growth Factor: A Prospective Case Series[J]. BMC Oral Health, 2025, 25(1):1064.
[18] Richardson DT, Dodson TB.Risk of Periodontal Defects after Third Molar Surgery: An Exercise in Evidence-Based Clinical Decision-Making[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005, 100(2):133-137.
[19] Li X, Yang H, Zhang Z, et al.Concentrated Growth Factor Exudate Enhances the Proliferation of Human Periodontal Ligament Cells in the Presence of TNF-α[J]. Mol Med Rep, 2019, 19(2):943-950.
[20] Yan Q, Li S, Yan Q, et al. A Genomic Compendium of Cultivated Human Gut Fungi Characterizes the Gut Mycobiome and Its Relevance to Common Diseases[J]. Cell, 2024, 187(12):2969-2989.e24.
[21] Zhu L, Du X, Fu G, et al.Efficacy of Different Forms of Concentrated Growth Factors Combined with Deproteinized Bovine Bone Minerals in Guided Bone Regeneration: A Randomized Clinical Trial[J]. BMC Oral Health, 2025, 25(1):320.
[22] Masuki H, Okudera T, Watanebe T, et al.Growth Factor and Pro-Inflammatory Cytokine Contents in Platelet-Rich Plasma (PRP), Plasma Rich in Growth Factors (PRGF), Advanced Platelet-Rich Fibrin(A-PRF), and Concentrated Growth Factors(CGF)[J]. Int J Implant Dent, 2016, 2(1):19.

A Randomized Controlled Clinical Study of Concentrated Growth Factor for Extraction of Mandibular Lower Impacted Third Molars

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