Abstract: Objective: To explore the multidisciplinary collaborative management protocol and long-term prognosis of multiple oral erythroleukoplakia. Diagnosis and Treatment: A 69-year-old female patient with multiple oral erythroleukoplakia underwent standardized diagnosis, treatment, and follow-up for 7 years. Comprehensive examinations including pathological biopsy, non-invasive detection technologies were performed to dynamically monitor disease progression. A multidisciplinary team (MDT) comprising specialists from the Department of Oral Mucosal Diseases, Department of Oral and Maxillofacial Surgery, and Department of Pathology collaborated to dynamically adjust treatment strategies based on lesion risk stratification, balancing lesion control, functional preservation, and the patient’s quality of life. Results: The patient experienced a complex clinical course characterized by improvement, recurrence, development of new lesions, and eventual stabilization. Following multidisciplinary collaboration and individualized treatment, long-term stable control of oral erythroleukoplakia was achieved without malignant transformation, oral function and the patient’s quality of life were maximally preserved. Notably, the patient underwent local perfusion chemotherapy with mitomycin due to bladder cancer in the later stage, and the oral leukoplakia disappeared accidentally. Conclusions: Close and regular follow-up, MDT, and risk-stratified management are crucial for improving the prognosis of patients with oral erythroleukoplakia. This study provides a reference for the clinical management of complex oral potentially malignant disorders(OPMDs). The disappearance of oral leukoplakia after chemotherapy provides new ideas for drug treatment.

Key words: oral erythroleukoplakia, multidisciplinary collaboration, photodynamic therapy, risk-stratified management, mitomycin