Abstract: Objective: To report the clinical effect of multidisciplinary combined treatment on secondary deformities after repair of adult unilateral complete cleft lip and palate. Diagnosis and Treatment: An 18-year-old male patient with congenital left complete cleft lip and palate had previously undergone cleft lip repair, cleft palate repair, and alveolar cleft repair. He was diagnosed with skeletal Class III malocclusion, facial asymmetry, nasolabial deformity, and dentition defect. The multidisciplinary treatment plan included preoperative orthodontic decompensation, orthognathic surgery (maxillary Le Fort I osteotomy with segmentation and bilateral sagittal split ramus osteotomy of the mandible), secondary nasolabial reconstruction, and postoperative orthodontic refinement and aesthetic restoration. Results: After treatment, the patient achieved symmetric dental arches, good occlusal relationship, coordinated jaw position, and improved nasolabial aesthetics. Conclusions: Multidisciplinary collaboration is the core strategy for sequential therapy of cleft lip and palate. Orthodontic treatment serves as a link to ensure the coherence of the treatment process. This combined plan effectively corrects maxillofacial deformities, enhances orofacial function and aesthetics, and has clinical guiding significance.

Key words: cleft lip and palate, secondary deformity, sequential therapy, multidisciplinary collaboration, oral and maxillofacial reconstruction