Research Progress on the Mechanism and Treatment of Medication-related Osteonecrosis of the Jaw

doi:10.12337/zgkqjxjyzz.2025.05.002

Chinese Journal of Stomatological Continuing Education ›› 2025, Vol. 28 ›› Issue (5): 307-311.DOI: 10.12337/zgkqjxjyzz.2025.05.002

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Research Progress on the Mechanism and Treatment of Medication-related Osteonecrosis of the Jaw

Jinyuan He, Guowen Sun^*

Department of Oral and Maxillofacial-Head and Neck Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Institute of Stomatology, Nanjing University, Nanjing, Jiangsu Province, P.R. China

Online:2025-09-30 Published:2025-09-30
Contact: Guowen Sun. Tel: 025-83620326. Email: 238957@sina.com. Address: No.30 Central Road, Xuanwu District, Nanjing 210008, Jiangsu Province, P.R. China.

Abstract

Abstract: Medication-related osteonecrosis of the jaw（MRONJ）is a serious complication that occurs in the jaw and is mainly related to the use of drugs such as antiresorptive and antiangiogenic drugs. This article reviews the latest research progress on the pathogenesis, risk factors, diagnostic methods, and prevention strategies of MRONJ. The pathogenesis of MRONJ involves the effects of drugs on bone metabolism, angiogenesis inhibition, local infection and immune response. Early diagnosis and prevention are essential to improve outcomes. At present, the treatment of MRONJ is mainly surgical, and there are also some emerging treatments, such as the synergistic therapy of pentoxifylline+α-tocopherol and the application of new technologies to assist in surgical treatment. Large-scale clinical studies are needed in the future to optimize the prevention and treatment strategies of MRONJ.

Key words: medication-related osteonecrosis of the jaw, antiresorptive drugs, antiangiogenic drugs, pathogenesis, treatment

Jinyuan He, Guowen Sun. Research Progress on the Mechanism and Treatment of Medication-related Osteonecrosis of the Jaw[J]. Chinese Journal of Stomatological Continuing Education, 2025, 28(5): 307-311.

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Research Progress on the Mechanism and Treatment of Medication-related Osteonecrosis of the Jaw

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