Research Progress on Photodynamic Therapy as an Adjuvant Treatment for Periodontitis

doi:10.12337/zgkqjxjyzz.2025.06.004

Chinese Journal of Stomatological Continuing Education ›› 2025, Vol. 28 ›› Issue (6): 398-404.DOI: 10.12337/zgkqjxjyzz.2025.06.004

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Research Progress on Photodynamic Therapy as an Adjuvant Treatment for Periodontitis

Jinghong Tan^1,3, Caiqing Qiu², Wei Guo^3,*

¹School of Stomatology, Binzhou Medical University, Yantai, Shandong Province, P.R. China;
²Department of Periodontics, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, Shandong Province, P.R. China;
³Department of Endodontics & Laser Clinic, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, Shandong Province, P.R. China

Online:2025-11-30 Published:2025-11-30
Contact: Wei Guo. Tel: 0535-6020127. Email: xyd_gw@163.com. Address: 1866 Guandanghe East Road, Laishan District, Yantai 264008, Shandong Province, P.R. China.
Supported by:
Yantai Science and Technology Innovation Development Program (No.2023YD056)

Abstract

Abstract: Photodynamic therapy (PDT) is a new type of antibacterial method. This technology works by generating cytotoxic reactive oxygen species to destroy the DNA and cell membranes of pathogenic bacteria, achieving the purpose of treatment. Due to its advantages of being less likely to develop drug resistance and having low toxicity and minimal invasiveness, in recent years, a large number of scholars have conducted a series of studies on the effectiveness of PDT as an adjuvant treatment for periodontitis. This article reviews the research progress of PDT in the adjunctive treatment of periodontitis, including its working principle, mechanism of action, clinical efficacy and application in special populations, as well as innovative applications such as the development of new photosensitizers, optimized nanodelivery systems, improvement of therapeutic devices, implementation of individualized treatment strategies and application of up-conversion nanoparticles, offering new ideas for the treatment of periodontitis.

Key words: periodontitis, photodynamic therapy, adjuvant therapy, clinical efficacy, special population applications

Jinghong Tan, Caiqing Qiu, Wei Guo. Research Progress on Photodynamic Therapy as an Adjuvant Treatment for Periodontitis[J]. Chinese Journal of Stomatological Continuing Education, 2025, 28(6): 398-404.

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Research Progress on Photodynamic Therapy as an Adjuvant Treatment for Periodontitis

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